This study seeks to develop and evaluate non-sputum based, biomarker-based tests for tuberculosis (TB), which is a leading priority for TB diagnostics research. Currently, we will focus on an enhanced assay for detecting lipoarabinomannan (LAM) antigen in urine, detection of Mycobacterium tuberculosis-derived DNA in plasma and urine, and a breath sensor that detects volatile organic compounds (VOCs) thought to be emitted by Mycobacterium tuberculosis. The accuracy of novel tests will be compared against a reference standard that is Gene Xpert® MTB/RIF and mycobacterial culture.